Global Search
Global Search

Trusted Resources: Education

Scientific literature and patient education texts

Back to Education / Scientific Articles

Sanfilippo Syndrome Type B: Analysis of Patients Diagnosed By the MPS Brazil Network

key information

source: American journal of medical genetics. Part A

year: 2021

authors: Montenegro YHA,de Souza CFM,Kubaski F,Trapp FB,Burin MG,Michelin-Tirelli K,Leistner-Segal S,Facchin ACB,Medeiros FS,Giugliani L,Ribeiro EM,Lourenço CM,Cardoso-Dos-Santos AC,Ribeiro MG,Kim CA,Castro MAA,Embiruçu EK,Steiner CE,Moreira MLC,Montano HQ,Baldo G,Giugliani R

summary/abstract:

Mucopolysaccharidosis type IIIB is a rare autosomal recessive disorder characterized by deficiency of the enzyme N-acetyl-alpha-d-glucosaminidase (NAGLU), caused by biallelic pathogenic variants in the NAGLU gene, which leads to storage of heparan sulfate and a series of clinical consequences which hallmark is neurodegeneration. In this study clinical, epidemiological, and biochemical data were obtained from MPS IIIB patients diagnosed from 2004-2019 by the MPS Brazil Network (“Rede MPS Brasil”), which was created with the goal to provide an easily accessible and comprehensive investigation of all MPS types. One hundred and ten MPS IIIB patients were diagnosed during this period. Mean age at diagnosis was 10.9 years. Patients were from all over Brazil, with a few from abroad, with a possible cluster of MPS IIIB identified in Ecuador. All patients had increased urinary levels of glycosaminoglycans and low NAGLU activity in blood. Main clinical symptoms reported at diagnosis were coarse facies and neurocognitive regression. The most common variant was p.Leu496Pro (30% of alleles). MPS IIIB seems to be relatively frequent in Brazil, but patients are diagnosed later than in other countries, and reasons for that probably include the limited awareness about the disease by health professionals and the difficulties to access diagnostic tests, factors that the MPS Brazil Network is trying to mitigate.

organization: Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

DOI: 10.1002/ajmg.a.62572

read more

Related Content

© 2024 rareLife solutions Inc.